Author
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5 papers
Recent·Most cited
Youri Hoogstrate, Santoesha A. Ghisai, Levi van Hijfte…·Pim J. French
The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.
W. R. Vallentgoed, Youri Hoogstrate, Karin A. van Garderen…·Pim J. French
The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.
Tamrin Chowdhury, C. Mircea S. Tesileanu, Emre Kocakavuk…·Roel G.W. Verhaak
This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.
Santoesha A. Ghisai, Levi van Hijfte, W. R. Vallentgoed…·Youri Hoogstrate
This study identifies DNA-methylation and RNA-expression signatures that improve grading of IDH-mutant astrocytomas beyond current methods.
Tathiane Maistro Malta, Thaís S. Sabedot, Natalia S. Morosini…·Peter S. LaViolette
This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.