A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells
E. C. Lerner, K. Woroniecka, V. D'Anniballe, D. Wilkinson, S. Lorrey, J. W. Polania, L. Wachsmuth, A. Miggelbrink, J. Raj, W. Tomaszewski, A. Mohan, X. Cui, M. Khasraw, M. D. Gunn, P. E. Fecci
This study shows CD8+ T cells can kill MHC-I-deficient tumor cells via NKG2D-NKG2DL interactions, independent of antigen recognition, and identifies this pathway as a potential therapeutic target.
bioRxiv · Feb 2, 2023 · PreprintImmunology