X. Cui

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

The paper identifies IL-1β as a factor that inhibits SARS-CoV-2-induced cell-cell fusion by promoting actin bundles, thereby restricting viral transmission.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

Microfluidic-enabled production of DNA barcoded APC library (MEDAL) for high throughput T cell epitope screening

The paper introduces MEDAL, a microfluidic platform for high-throughput T cell epitope screening by producing DNA-barcoded APCs loaded with peptides, enabling efficient identification of MHC-binding peptides.

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

Multiomic Screening Unravels the Immunometabolic Signatures and Drug Targets of Age-Related Macular Degeneration

This study uses multiomic methods to identify immunometabolic pathways and drug targets in AMD, highlighting key genes and pathways involved in disease progression and potential therapeutic interventions.

Identification of a distinct cluster of GDF15high macrophages exhibiting anti-inflammatory activities

The paper identifies a distinct cluster of GDF15high macrophages with anti-inflammatory properties using single-cell RNA sequencing and functional assays.

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

Aminomutation catalyzed by CO2 self-sufficient cascade amino acid decarboxylases

This paper describes an in vitro biotransformation pathway using two decarboxylases to convert -alanine to {beta}-alanine with 100% carbon atom economy by fixing CO2.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Short Tandem Repeat Profiling via Next Generation Sequencing for Cell Line Authentication

This study compares NGS-based STR profiling with traditional STR-CE for cell line authentication, finding NGS offers better sequence context, sensitivity, and multiplexing.

A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells

This study shows CD8+ T cells can kill MHC-I-deficient tumor cells via NKG2D-NKG2DL interactions, independent of antigen recognition, and identifies this pathway as a potential therapeutic target.

A pilot study of stable isotope fractionation in Bombyx mori rearing

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3

This study determines the cryo-EM structure of human CaV2.3 channels and identifies key residues and interactions involved in channel gating and inactivation.

Autophagy protects against high-dose Mycobacterium tuberculosis infection

This study shows autophagy in myeloid cells protects against high-dose Mycobacterium tuberculosis infection by limiting myeloid-derived suppressor cells and promoting T cell responses, distinct from its role in low-dose infection.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

A SHR-IDD-PIN regulatory network mediates minor vein differentiation in rice

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

Glabridin induces paraptosis-like cell death via ER stress in breast cancer cells

This study shows glabridin induces paraptosis-like cell death in breast cancer cells by causing ER stress and mitochondrial dysfunction.

The multi-BRCT domain protein DDRM2 is required for homologous recombination in plants

A genetic screen in Arabidopsis identifies DDRM2, a multi-BRCT domain protein required for homologous recombination and regulated by SOG1.

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

This study identifies Lrp1 as a host factor required for Oropouche orthobunyavirus infection and suggests a broader role for Lrp1 in bunyavirus entry.

Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer Cells

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

Homogeneous environmental selection overturns distance-decay relationship of soil prokaryotic community

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

A Facile and Rapid Route to Self-Digitization of Samples into a High Density Microwell Array for Digital Bioassays

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

Microtubule-associated ROP interactors both delimit and transduce ROP signaling and regulate microtubule dynamics

This study identifies ICR2 and its homologs as regulators of ROP signaling and microtubule dynamics in Arabidopsis.

MiRNA-223 Inhibits MouseGallstone Formation by Targeting Key Transporters in Hepatobiliary Cholesterol Secretion Pathway

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.

Epigenetic Interaction between UTX and DNMT1 Regulates Diet-Induced Myogenic Remodeling in Brown Fat

The paper shows that the interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat by maintaining brown adipocyte identity and thermogenic function.

Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

Length of Mucin-Like Domains Enhance Cell-Ebola Virus Adhesion by Increasing Binding Probability

This study models TIM-PS adhesion to show longer MLDs increase binding probability, enhancing Ebola virus adhesion through increased surface sampling.

Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue

This study identifies NTF3 as a fat-derived neurotrophic factor that regulates sympathetic innervation and thermogenesis in adipose tissue, influencing energy metabolism and obesity.

Menthol in Electronic Cigarettes: A Contributor to Respiratory Disease?

This study investigates how menthol in e-cigarettes affects human bronchial epithelium using three in vitro models, finding adverse effects including oxidative stress and inflammation.