Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth
R. L. Wilson, W. Troja, E. K. Sumser, A. Maupin, K. Lampe, H. N. Jones
This study shows that endothelial nitric oxide synthase is required for IGF1 signaling in placenta cells to support fetal growth, as IGF1 gene therapy failed to restore growth in eNOS-deficient mice.
bioRxiv · Aug 21, 2020Physiology