IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1beta secretion
A. Dinarello, M. May, J. Amo-Aparicio, T. Azam, J. M. Gaballa, C. Marchetti, A. Tesoriere, R. Ghirardo, J. S. Redzic, W. Webber, S. M. Atif, S. Li, E. Z. Eisenmesser, D. M. de Graaf, C. A. Dinarello
This paper shows IL-38 promotes intestinal stem cell growth by enhancing WNT signaling and beneficial IL-1beta secretion, while also having anti-inflammatory effects in the small intestine.
bioRxiv · Apr 4, 2023Cell Biology