Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity
Y. JIA, G. Shen, S. Nguyen, Y. Zhang, K.-S. Huang, H.-Y. Ho, W.-S. Hor, C.-H. Yang, J. B. Bruning, C. Li, W.-L. Wang
The paper analyzes SARS-CoV-2 mutation dynamics, showing lower mutation rates than SARS and identifying an ACE2-binding affinity-reducing RBD mutation from an Indian sample collected in January 2020.
bioRxiv · Apr 9, 2020 · PreprintEvolutionary Biology