Y. Jia

ESPRESSO: Spatiotemporal omics based on organelle phenotyping

ESPRESSO provides high-dimensional spatiotemporal phenotyping of organelles using fluorescent labeling and advanced microscopy, enabling analysis of cell states, stress response, and immune cell polarization.

Protective Effect of 2-Hydroxyestrone and2-Hydroxyestradiol Against Chemically-Induced Hepatotoxicity In Vitro and In Vivo

This study shows that 2-hydroxyestrone and 2-hydroxyestradiol protect against ferroptosis in hepatoma cells and acetaminophen-induced liver injury by inhibiting PDI activity and reducing NO, ROS, and lipid-ROS accumulation.

Synthetic bacterial consortium for degradation of plastic pyrolysis oil waste

This paper develops a synthetic bacterial consortium to degrade plastic pyrolysis oil waste, achieving high removal efficiencies for alkanes and aromatic hydrocarbons, and uses a neural network to model microbial activity.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Cyclocarya paliurus polysaccharides improve high fat diet-fed mice lipid dysmetabolism through gut microbiota

This study shows Cyclocarya paliurus polysaccharides reduce obesity and lipid dysmetabolism in high fat diet-fed mice by modulating gut microbiota.

Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION

This study shows that dopamine D4 receptor reduces NCC protein levels by promoting its ubiquitination and lysosomal degradation in mice.

Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

Metabolomics unveiled the impact of alterations in nucleotide glucose metabolism on palmitic acid-induced TLR4 activation in THP-1 macrophages

This study uses metabolomics to show that palmitic acid alters N-glycosylation-related metabolites in THP-1 macrophages, linking them to TLR4 activation and inflammation.

Optimization for High-Throughput BiFC screening

The paper discusses the Cell-PCA screen's role in analyzing cellular interactomes and identifies areas for optimization to maintain its relevance with advancing biotechnology.

Trifunctional linkers enable improved visualization of actin by expansion microscopy

The paper introduces TRITON trifunctional linkers to improve actin visualization in expansion microscopy, achieving better signal retention and anchoring.

Computational ranking-assisted identification of Plexin-B2 in homotypic and heterotypic clustering of circulating tumor cells in breast cancer metastasis

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

100 years of anthropogenic impact causes changes in freshwater functional biodiversity

The paper uses AI to analyze 100 years of freshwater biodiversity data, showing that insecticides, fungicides, and climate factors explain most functional biodiversity changes.

Extra-cellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: a potential driver of prostate cancer aggressiveness

The paper defines abundant periprostatic adipose tissue using a statistical approach and shows it is associated with prostate cancer aggressiveness through extracellular matrix remodeling.

The Solanum americanum pangenome and effectoromics reveal new resistance genes against potato late blight

The paper identifies novel resistance genes in Solanum americanum against Phytophthora infestans by analyzing genome variation and effector recognition.

A Self-Healing, Viscoelastic Hydrogel Promotes Healing of Brain Lesions

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

The tissue-specific chromatin accessibility landscape of Papaver somniferum

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration

The paper identifies SNIP1 and RNPS1 as a molecular brake that causes spliceosome pausing at detained introns, contributing to neurodegeneration.

Assessment of chimeric antigen receptor T (CAR-T) cytotoxicity by droplet microfluidics in vitro

This study presents a droplet microfluidic assay to assess CAR-T cytotoxicity in vitro, enabling analysis of activity, expansion, and mechanism under varying conditions.

Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritis

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

Diversity, function and evolution of marine microbe genomes

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

Structure insights of the human peroxisomal ABC transporter ALDP

The paper reports the cryo-EM structure of human ALDP, revealing its conformation and potential lipid-binding site, which aids in understanding disease-causing mutations.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Modelling, Analysis, and Optimization of Three-Dimensional Restricted Visual Field Metric-Free Swarms

This paper develops a three-dimensional restricted visual field metric-free model to study swarm consistency and finds that optimal restricted angles improve flock cohesion compared to global visual fields.

High-speed widefield handheld swept-source OCT angiography with a VCSEL light source

This paper presents a high-speed handheld OCT/OCTA system for retinal imaging in clinical settings, demonstrating its use in neonatal and surgical patients.

Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.