Author

J. B. Bruning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. D. Abell· 1 shared A. P. Thompson· 1 shared B. I. Gaiser· 1 shared C. J. Sumby· 1 shared C. Li· 1 shared C.-H. Yang· 1 shared G. Shen· 1 shared H.-Y. Ho· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. D. Abell

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2 papers

Recent·Most cited

Fortuitous in vitro compound degradation produces a tractable hit against Mycobacterium tuberculosis dethiobiotin synthetase: a cautionary tale of what goes in, does not always come out

W. Salaemae, A. P. Thompson, B. I. Gaiser, K. J. Lee, M. T. Huxley, C. J. Sumby, S. W. Polyak, A. D. Abell, J. B. Bruning, K. L. Wegener

The paper describes how a fragment compound was inadvertently modified in crystal conditions, leading to a potent inhibitor of Mycobacterium tuberculosis dethiobiotin synthetase.

bioRxiv · Mar 26, 2023 · PreprintBiochemistry

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity

Y. JIA, G. Shen, S. Nguyen, Y. Zhang, K.-S. Huang, H.-Y. Ho, W.-S. Hor, C.-H. Yang, J. B. Bruning, C. Li, W.-L. Wang

The paper analyzes SARS-CoV-2 mutation dynamics, showing lower mutation rates than SARS and identifying an ACE2-binding affinity-reducing RBD mutation from an Indian sample collected in January 2020.

bioRxiv · Apr 9, 2020 · PreprintEvolutionary Biology