Mechanistic Investigation of Reversible Hibernation-Driven Immune Suppression in Thirteen-Lined Ground Squirrels
Miaoyun Zhao, Jackson Chen, Rachel Burrett, Weilong Yang, Subhra Mandal, Saroj Chandra Lohani, Chi Zhang, Jayamanna M. Wickramasinghe, Matthew T. Andrews, Qingsheng Li
This study investigates immune suppression during torpor in 13-lined ground squirrels using single-cell RNA sequencing and image analysis, identifying metabolic and lineage-specific programs that conserve energy while preserving immune function.
bioRxiv · Sep 21, 2026 · PreprintImmunology