Author

Wenling Li

National Heart, Lung, and Blood Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Chang Liu· 1 shared Cheng ZhuiD· 1 shared Chengyu LiuiD· 1 shared Chenyu LuaniD· 1 shared Haitao YangiD· 1 shared Qianfan Wang· 1 shared Ryo Sato· 1 shared Sadhana JacksoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Chang Liu

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2 papers

Recent·Most cited

Structural basis for loop-dependent inhibition by AcrIIC1 anti-CRISPR proteins

Shen Wang, Zhiyu Zhang, Chenyu Luan, Cheng Zhu, Wenling Li, Qianfan Wang, Xiaoqian Liu, Haitao Yang, Yunjie Xiao, Zefang Wang

This study identifies a loop-dependent inhibitory mechanism in AcrIIC1 anti-CRISPR proteins, showing how a unique loop enhances inhibition by disrupting sgRNA binding and R-loop maturation.

bioRxiv · Jun 11, 2026 · PreprintMolecular Biology

ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM

Sara González-Hernández, Ryo Sato, Yuya Sato, Chang Liu, Wenling Li, Zulfeqhar Ali Syed, Chengyu Liu, Sadhana Jackson, Yoshiaki Kubota, Yoh‐suke Mukouyama

This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.

JCI Insight · Jan 1, 2026Peer-reviewedDevelopmental Biology