Non-canonical TERT function mitigates adipose tissue inflammation in obesity by modulating stem cell-macrophage communication and macrophage states
Laura Braud, Andrea Ninni, Antonio M.A. Miranda, Émilie Baudelet, Julien Vernerey, Marina Villaverde, Francesca Sciarretta, Manuel Bernabe, Léa Girondier, Ilaria Elia, Jesús Gil, Stéphane Audebert, Jean‐Marc Brondello, Christophe Lachaud, Will Scott, , Vincent Géli
This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.
bioRxiv · Dec 18, 2025 · PreprintPhysiology