Author

Wing-Lee Chan

Charité – Universitätsmedizin Berlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lars WittleriD· 3 shared Alexandra DespangiD· 2 shared Christina PaliouiD· 2 shared Daniel M. IbrahimiD· 2 shared Martin FrankeiD· 2 shared Robert Schöpflin· 2 shared Stefan MundlosiD· 2 shared Alessa R. RingeliD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersDevelopmental Biology

Lars WittlerORCID

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Author profile →

3 papers

Recent·Most cited

Enhancer adoption by an LTR retrotransposongenerates viral-like particles causingdevelopmental limb phenotypes

Juliane Glaser, Giulia Cova, Beatrix Fauler, Cesar A. Prada‐Medina, Virginie Stanislas, Mai H.Q. Phan, Robert Schöpflin, Yasmin Aktas, Martin Franke, Guillaume Andrey, Natalia Bartzoka, Christina Paliou, Verena Laupert, Wing-Lee Chan, Lars Wittler, , Stefan Mundlos

The paper shows that activation of an LTR retrotransposon in the embryo leads to viral-like particle production, causing limb malformations through apoptotic cell death.

Nature Genetics · Jul 1, 2025Peer-reviewedDevelopmental Biology

Single cell, whole embryo phenotyping of pleiotropic disorders of mammalian development

Xingfan Huang, Jana Henck, Chengxiang Qiu, Varun K. A. Sreenivasan, Saranya Balachandran, Rose Yinghan Behncke, Wing-Lee Chan, Alexandra Despang, Diane E. Dickel, Natja Haag, René Hägerling, Nils Rouven Hansmeier, Friederike Hennig, Cooper Marshall, Sudha Sunil Rajderkar, , Malte Spielmann

The paper uses single-cell RNA sequencing to systematically phenotype mouse genetic models, identifying molecular and cellular changes across multiple mutants and wildtypes.

bioRxiv · Aug 3, 2022 · PreprintGenomics

Functional dissection of TADs reveals non-essential and instructive roles in regulating gene expression

Alexandra Despang, Robert Schöpflin, Martin Franke, Salaheddine Ali, Ivana Jerković, Christina Paliou, Wing-Lee Chan, Bernd Timmermann, Lars Wittler, Martin Vingron, Stefan Mundlos, Daniel M. Ibrahim

The paper investigates TAD function in mice by editing TAD organization, finding that TADs provide robustness but are not essential for gene regulation, and that disease phenotypes arise from re-direction of regulatory contacts.

bioRxiv · Mar 5, 2019 · PreprintGenetics