In-cell destabilization of a homo-dimeric protein complex detected by DEER spectroscopy
Y. Yang, S.-N. Chen, F. Yang, X. Y. Li, A. Feintuch, X.-C. Su, D. Goldfarb
This study uses DEER spectroscopy to show that a homo-dimeric protein complex is destabilized in human cells compared to solution, challenging excluded volume crowding theory.
Proceedings of the National Academy of Sciences · Aug 11, 2020Peer-reviewedBiophysics