F. Yang

Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastoma

This study identifies cellular and molecular mechanisms of tertiary lymphoid structure (TLS) formation in glioblastoma, showing TLS correlate with improved survival and are driven by CD4 T cells expressing lymphotoxin β.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Clostridium ablates tumors by degrading collagen mesh andinducing ferroptosis

This paper describes a Clostridium strain that degrades collagen and induces ferroptosis in tumors, leading to effective tumor destruction in mice.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

Resistance to Naive and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells

This study characterizes a new pluripotent state in RSeT hESCs, showing resistance to naive and formative conversion and distinct transcriptomic and signaling features.

Variant Surface Protein GP60 Contributes to Host Infectivity of Cryptosporidium parvum

The paper investigates the role of GP60 in Cryptosporidium parvum infectivity, finding that while GP60 is not essential, its cleavage products affect parasite growth and infection severity.

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

The study identifies SKSR1 as a key virulence factor in Cryptosporidium by crossing isolates with different virulence and analyzing genetic loci associated with infectivity.

The Mechanism Insight into Bacterial Degradation of Pentachlorobiphenyl

This study identifies a new bacterium capable of degrading pentachlorobiphenyl and characterizes its enzymatic, proteomic, and metabolomic responses to the pollutant.

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

CSTA: A Biomarker Regulating Esophageal Stricture Epithelial Barrier, Potential Medication Target

The paper identifies CSTA as a biomarker for esophageal epithelial barrier function and shows FK506 can rescue CSTA-knockdown effects in strictures.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

Leaf δ13C reveals post-photosynthetic fractionation during ontogeny in a C4 grass

The paper investigates post-photosynthetic fractionation effects on δ13C in a C4 grass, finding that δ13C of cellulose is more reliable for predicting physiological parameters than δ13C of bulk organic matter.

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

This study shows TRIP13 localizes to synapsed chromosomes and is a dosage-sensitive regulator of meiosis, with loss leading to sterility and meiotic defects.

A bacterial effector directly targets Arabidopsis Argonaute 1 to suppress Pattern-triggered immunity and cause disease

This study shows that the bacterial effector HopT1-1 targets Arabidopsis AGO1 to suppress miRNA function and PTI, leading to disease.

Metabolomics-assisted mechanism analysis of gamma-PGA synthesis regulated by PhoP in B. licheniformis

This study shows PhoP directly regulates {gamma}-PGA synthesis in B. licheniformis and indirectly affects it through glutamate transport, nitrogen utilization, and ammonia assimilation.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

Quantifying Amide-Aromatic Interactions at Molecular and Atomic Levels: Experimentally-determined Enthalpic and Entropic Contributions to Interactions of Amide sp2O, N, C and sp3C Unified Atoms with Naphthalene sp2C Atoms in Water

The paper quantifies enthalpic and entropic contributions of amide-aromatic interactions in water, revealing their thermodynamic driving forces and relevance to protein processes.

A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli

The paper identifies a temperature-sensitive metabolic valve and a transcriptional feedback loop in E. coli that enable rapid homeoviscous adaptation to temperature changes.

Reduced binding associated with resistance to Vip3Aa in the corn earworm (Helicoverpa zea)

This study identifies reduced Vip3Aa binding to midgut receptors as the resistance mechanism in a Vip3Aa-resistant strain of Helicoverpa zea.

A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission

This paper introduces a pseudovirus-based method to mimic SARS-CoV-2 cell-to-cell fusion and transmission, demonstrating its utility for screening inhibitors and studying variant fusogenic ability.

A novel mitochondrial regulon for Ferroptosis during fungal pathogenesis

This study identifies a mitochondrial regulon essential for ferroptosis in the fungal pathogen Magnaporthe oryzae, linking mitochondrial metabolism and redox regulation to fungal pathogenesis.

Complement C3 reduces apoptosis in human cardiomyocytes

This study shows exogenous Complement C3 reduces apoptosis in human cardiomyocytes by interacting with the intrinsic apoptotic pathway.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Hierarchical Clustering and Omics Analysis Revealed Massive Molecular Shifts in a Tree under Combined Hypoxia and Salinity

This study identifies molecular shifts in Dalbergia odorifera under combined hypoxia and salinity through transcriptomic and metabolic analysis.

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

This study shows that oral administration of indole-3-acetate reduces liver steatosis and inflammation in mice fed a high-fat diet.