Author

A. Feintuch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Organism:E. coli· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

D. Goldfarb· 3 shared B. E. Clifton· 1 shared C. J. Jackson· 1 shared E. Bibi· 1 shared E. H. Yardeni· 1 shared F. Yang· 1 shared G. Otting· 1 shared J. A. Kaczmarski· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

D. Goldfarb

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3 papers

Recent·Most cited

Drug binding sites in the multidrug transporter MdfA in detergent solution and in lipid nanodiscs

D. Goldfarb, T. Bahrenberg, E. H. Yardeni, A. Feintuch, E. Bibi

This paper uses DEER spectroscopy to determine the binding site of a drug analog in MdfA and examines conformational changes in detergent micelles and lipid nanodiscs.

bioRxiv · Aug 31, 2020Biophysics

In-cell destabilization of a homo-dimeric protein complex detected by DEER spectroscopy

Y. Yang, S.-N. Chen, F. Yang, X. Y. Li, A. Feintuch, X.-C. Su, D. Goldfarb

This study uses DEER spectroscopy to show that a homo-dimeric protein complex is destabilized in human cells compared to solution, challenging excluded volume crowding theory.

Proceedings of the National Academy of Sciences · Aug 11, 2020Peer-reviewedBiophysics

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

J. A. Kaczmarski, M. C. Mahawaththa, A. Feintuch, B. E. Clifton, L. A. Adams, D. Goldfarb, G. Otting, C. J. Jackson

The paper investigates how remote mutations alter conformational sampling along an evolutionary trajectory, increasing catalytic activity in an enzyme.

bioRxiv · Feb 3, 2020Biochemistry