BiochemistrybioRxivPreprint
Replicating enzymatic activity by positioning active sites with synthetic protein scaffolds
Yujing Ding, Shanshan Zhang, Henry Hess…·Yifei Zhang
The paper demonstrates a computational strategy to design new PET hydrolases by replicating functional motifs from a template enzyme using deep learning and molecular computations, resulting in enzymes with high activity and thermostability.
DOI 10.1101/2024.01.31.577620