Cancer BiologybioRxivPreprint
5β-Dihydrotestosterone reveals a mutant androgen receptor vulnerability in prostate cancer
Samual Adams, Lindsey Phelan, Therese Lewis…·Jianneng Li
This paper evaluates 5β-Dihydrotestosterone (5β-DHT) as a potential alternative to testosterone in bipolar androgen therapy (BAT) for prostate cancer, showing it activates AR signaling in mutant AR contexts and suppresses tumor growth with fewer side effects.
DOI 10.64898/2026.07.14.738538