Xiangnan Guan

This study examines liver transcriptional changes during lactation and weaning in mice, finding similarities between liver involution and pre-metastatic niches, with implications for breast cancer metastasis.

This study shows that inhibiting ACSLs in multiple myeloma cells reduces proliferation and causes mitochondrial dysfunction, suggesting ACSLs as potential therapeutic targets.

PENCIL identifies phenotype-relevant cell subpopulations from single-cell data using a supervised learning framework with feature selection and trajectory prediction capabilities.

Scissor identifies cell subpopulations from single-cell data correlated with specific phenotypes using clinical information, revealing biologically relevant subpopulations in lung and melanoma cancers.