Pentose Sugars Encode Sequence-Dependent DNA-RNA Segregation for Programmable Engineering of Multiphase Condensates
Wei Peng Guo, Feipeng Chen, Andrew B. Kinghorn, Xiufeng Li, Haohui Ou, Yi Pan, Rong Luo, Yuchao Wang, Kwan Kiu Lau, Tianjiao Mao, Zhenyu Yang, Xiaolai Li, Ying Chen, Sihan Liu, Yage Zhang, , Ho Cheung Shum
The paper shows that a single sugar difference between DNA and RNA drives phase segregation with cationic peptides, enabling programmable synthetic condensates that mimic nuclear compartments.
bioRxiv · Jun 23, 2025 · PreprintBiophysics