Author

Chen Wu

Case Western Reserve University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Belinda B. WillardiD· 1 shared Chengqi LiniD· 1 shared Chun-Peng PaiiD· 1 shared Chunyan ZhaoiD· 1 shared Dongbing Tao· 1 shared Feiyu AniD· 1 shared Gina Lin· 1 shared Haisu ShiiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Belinda B. WillardORCID

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Author profile →

4 papers

Recent·Most cited

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

Han Wang, Zixi Yun, Yuan Cao, Xinyue Li, Zhenghao Liu, Chun-Peng Pai, Chen Wu, Junrong Yue, Gina Lin, Jackie Cai, Belinda B. Willard, Sichun Yang, Ruth A. Keri, William P. Schiemann, John Alan Diehl, Hung‐Ying Kao

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.

bioRxiv · May 15, 2025 · PreprintCancer Biology

Saccades orchestrate intraocular glucose to shape visual responses in birds

Xi Xu, Tong Xiao, Yibing Chen, Lijuan Song, Chen Wu, Qian Wang, Tao Zhang, Yan Qin Yang

This study shows that oscillatory saccades in pigeons regulate intraocular glucose levels, linking eye movements to metabolic dynamics and visual processing.

bioRxiv · Apr 17, 2025 · PreprintNeuroscience

Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

Peng Xie, Xu Jiang, Jingjing He, Qingyun Pan, Xianfa Yang, Yanying Zheng, Zhuanzhuan Che, Wenli Fan, Chen Wu, Weiheng Zheng, Shuhan Si, Kun Gao, Shiqi Zhu, Ke Fang, Haitong Fang, , Chengqi Lin

The paper uses single-cell multi-omics to study early cardiac lineage specification in mouse embryos, identifying key transcription factors and regulatory networks.

bioRxiv · May 17, 2024 · PreprintMolecular Biology

Both Determinants of Allosteric and Active Sites Responsible for Catalytic Activity of Delta 12 Fatty Acid Desaturase by Domain Swapping

Haisu Shi, Jinlong Tian, Chen Wu, Mo Li, Feiyu An, Rina Wu, Junhua Shao, Yan Zheng, Xue Gang Luo, Dongbing Tao, Xu Chen, Yuzhen Pi, Chunyan Zhao, Xiqing Yue, Junrui Wu

This study identifies key amino acid residues and domains in FADS12 that influence catalytic activity and inhibition through domain swapping between two fungal species.

bioRxiv · Oct 1, 2019 · PreprintMolecular Biology