Age of the bone marrow dictates clonality of smooth muscle-derived cells in the atherosclerotic plaque
I. Kabir, X. Zhang, J. Dave, R. Chakraborty, R. Qu, R. R. Chandran, A. Ntokou, E. Gallardo-Vara, B. Aryal, N. Rotllan, R. Garcia-Milian, J. Hwa, Y. Klugar, K. A. Martin, C. Fernandez-Hernando, D. M. Greif
This study shows that aged bone marrow-derived cells increase smooth muscle cell polyclonality in atherosclerotic plaques through reduced TET2 and increased TNF signaling.
bioRxiv · Jan 18, 2022Cell Biology