Patient-derived tumor organoids from resected non-small cell lung cancers for high-throughput response testing with approved and repurposed drugs
K. N. Suvilesh, Y. Manjunath, Y. I. Nussbaum, M. Gadelkarim, A. Srivastava, G. Li, W. C. Warren, C.-R. Shyu, F. Gao, M. Ciorba, J. B. Mitchem, S. Rachagani, J. T. Kaifi
This study develops patient-derived tumor organoids from non-metastatic NSCLC tumors to test drug responses and identify chemoresistance mechanisms, finding 50% of organoids were chemo-resistant and could be sensitized by repurposed drugs.
bioRxiv · Oct 18, 2023 · PreprintCancer Biology