Genome-scale CRISPR-Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection.
M. Sakai, Y. Masuda, Y. Tarumoto, N. Aihara, Y. Tsunoda, M. Iwata, Y. Kamiya, R. Komorizono, T. Noda, K. Yusa, K. Tomonaga, A. Makino
The paper identifies TRIM28, TRIM33, EHMT1, and EHMT2 as novel host factors involved in SARS-CoV-2 infection and shows that EHMT1/2 inhibition reduces viral growth and disease severity.
bioRxiv · Mar 6, 2023Microbiology