MicrobiologybioRxiv
Genome-scale CRISPR-Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection.
M. Sakai, Y. Masuda, Y. Tarumoto…·A. Makino
The paper identifies TRIM28, TRIM33, EHMT1, and EHMT2 as novel host factors involved in SARS-CoV-2 infection and shows that EHMT1/2 inhibition reduces viral growth and disease severity.
DOI 10.1016/j.isci.2024.110475