Author

Y. Sagae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

G.-J. Bekker· 2 shared M. Araki· 2 shared N. Kamiya· 2 shared S. Matsumoto· 2 shared Y. Isaka· 2 shared Y. Okuno· 2 shared H. Kokubo· 1 shared K. Takemura· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

G.-J. Bekker

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2 papers

Recent·Most cited

Molecular dynamics unveils multiple-site binding of inhibitors with reduced activity on the surface of dihydrofolate reductase

M. Araki, T. Ekimoto, K. Takemura, S. Matsumoto, Y. Tamura, H. Kokubo, G.-J. Bekker, T. Yamane, Y. Isaka, Y. Sagae, N. Kamiya, M. Ikeguchi, Y. Okuno

This study uses molecular dynamics to analyze inhibitor binding to DHFR, showing that reduced activity correlates with multiple-bound states on the protein surface.

bioRxiv · Mar 27, 2024Biophysics

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics

M. Araki, S. Matsumoto, G.-J. Bekker, Y. Isaka, Y. Sagae, N. Kamiya, Y. Okuno

This study accelerates molecular dynamics simulations using ultrasound to study ligand binding pathways on proteins, revealing previously undetectable kinetic features and binding pathways.

bioRxiv · Apr 6, 2020Biophysics