Author

M. Araki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:protein structure· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

G.-J. Bekker· 2 shared N. Kamiya· 2 shared S. Matsumoto· 2 shared Y. Isaka· 2 shared Y. Okuno· 2 shared Y. Sagae· 2 shared A. Beavers· 1 shared A. Oishi· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

G.-J. Bekker

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Molecular dynamics unveils multiple-site binding of inhibitors with reduced activity on the surface of dihydrofolate reductase

M. Araki, T. Ekimoto, K. Takemura, S. Matsumoto, Y. Tamura, H. Kokubo, G.-J. Bekker, T. Yamane, Y. Isaka, Y. Sagae, N. Kamiya, M. Ikeguchi, Y. Okuno

This study uses molecular dynamics to analyze inhibitor binding to DHFR, showing that reduced activity correlates with multiple-bound states on the protein surface.

bioRxiv · Mar 27, 2024Biophysics

LAG3 regulates antibody responses in a murine model of kidney transplantation

M. Nicosia, R. Fan, J. Lee, V. Gorbacheva, J. I. Valenzuela, Y. Yamamoto, A. Beavers, N. Dvorina, E. Chuluyan, M. Araki, W. Baldwin, R. L. Fairchild, B. Min, A. Valujskikh

This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.

bioRxiv · Jan 31, 2022 · PreprintImmunology

Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety

H. Watari, H. Kageyama, N. Masubuchi, H. Nakajima, K. Onodera, P. J. Focia, T. Oshiro, T. Matsui, Y. Kodera, T. Ogawa, T. Yokoyama, M. Hirayama, K. Hori, D. M. Freymann, N. Komatsu, , R. Sakai

A marine sponge-derived lectin activates the thrombopoietin receptor by promoting dimerization and exhibits synergy with thrombopoietin, affecting receptor internalization.

bioRxiv · Oct 29, 2021 · PreprintCell Biology

BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice

M. Araki, G. Ito, S. Takatori, T. Tomita

The paper investigates the role of LRRK2 and BORCS6 in lung lamellar body morphology using mouse models and cell cultures, finding that BORCS6 deficiency leads to enlarged lamellar bodies.

bioRxiv · Mar 5, 2021Cell Biology

Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition

H. Shimano, Y. Nakagawa, Y. Yunong Wang, S.-i. Han, K. Okuda, A. Oishi, Y. Yagishita, K. Kumagai, H. Ohno, Y. Osaki, Y. Mizunoe, Y. Murayama, H. Iwasaki, M. Konishi, N. Itoh, , M. Araki

This study shows CREB3L3 protects against atherosclerosis by inhibiting SREBP activity through competitive antagonism, reducing lipogenic and cholesterogenic gene expression.

bioRxiv · Apr 29, 2020Physiology

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics

M. Araki, S. Matsumoto, G.-J. Bekker, Y. Isaka, Y. Sagae, N. Kamiya, Y. Okuno

This study accelerates molecular dynamics simulations using ultrasound to study ligand binding pathways on proteins, revealing previously undetectable kinetic features and binding pathways.

bioRxiv · Apr 6, 2020Biophysics

Phosphorylation of the Anaphase Promoting Complex activator CDH1/FZR regulates the transition from Meiosis I to Meiosis II in mouse male germ cell

N. Tanno, S. Kuninaka, S. Fujimura, K. Okamura, K. Takemoto, K. ARAKI, M. Araki, H. Saya, K.-i. Ishiguro

This study shows that phosphorylation of CDH1 is essential for the transition from meiosis I to meiosis II in mouse male germ cells and for spermatogonial stem cell maintenance.

bioRxiv · Mar 13, 2020Cell Biology