Author

Yan Poon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:graph neural network· 1 Assay:imaging· 1

Frequent Co-Authors

Ashleigh SmirnoviD· 1 shared Bede PortziD· 1 shared Ben E. BlackiD· 1 shared Bo Lim LeeiD· 1 shared Brigid K. JenseniD· 1 shared Busra OzguneyiD· 1 shared Christopher J. DonnellyiD· 1 shared Cristian A BergmanniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ashleigh SmirnovORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A Generative Virtual Tissue Model Enables Computational Design of Therapeutic Perturbation Strategies

Yunrui Lu, Willis Zhang, Yu-Jen Chen, Jiayi Yin, Lydia Chen, Kevin Fleisher, James Gornet, Rex Liu, Zitong Jerry Wang, Yan Poon, Yuning You, Matt W. Thomson

This paper introduces CIFM, a generative virtual tissue model that simulates transcriptional dynamics under therapeutic conditions to design immunotherapy strategies for cancer and autoimmune diseases.

bioRxiv · Aug 20, 2026 · PreprintBioinformatics

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson, Qizan Chen, Busra Ozguney, Marilyn Ngo, Longxin Xie, Ashleigh Smirnov, Matt Davis, Leland C. Mayne, Miriam Linsenmeier, Jack D. Rubien, Cristian A Bergmann, Bede Portz, Bo Lim Lee, , James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

Science · May 7, 2026Peer-reviewedBiochemistry✦ In-depth digest