Author

Bo Lim Lee

University of PennsylvaniaORCID 0009-0004-8999-3295Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Bo Lim Lee1 paper · University of Pennsylvania

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

Ashleigh SmirnoviD· 2 shared Bede PortziD· 2 shared Christopher J. DonnellyiD· 2 shared Hana M. OdehiD· 2 shared Jack D. RubieniD· 2 shared James ShorteriD· 2 shared Jocelyn C. MaunaiD· 2 shared Katie E. CopleyiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Ashleigh SmirnovORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrySciencePeer-reviewedMay 7, 2026

✦ In-depth digest

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson…·James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

20 citationstop 1%

𝕏 PostBluesky

BiochemistrybioRxivSep 4, 2023

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

Lin Guo, Jacob R. Mann, Jocelyn C. Mauna…·James Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

DOI 10.1016/j.molcel.2025.12.009

humanbulk RNA-seq

𝕏 PostBluesky