Author

Katie E. Copley

University of PennsylvaniaORCID 0000-0003-0422-7475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

James ShorteriD· 3 shared Ashleigh SmirnoviD· 2 shared Bede PortziD· 2 shared Bo Lim LeeiD· 2 shared Christopher J. DonnellyiD· 2 shared Hana M. OdehiD· 2 shared Jack D. RubieniD· 2 shared Jocelyn C. MaunaiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

James ShorterORCID

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3 papers

Recent·Most cited

BiochemistrySciencePeer-reviewedMay 7, 2026

✦ In-depth digest

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson…·James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

20 citationstop 1%

humanmouse

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BiochemistrybioRxivPreprintMay 10, 2025

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity

Edward M. Barbieri, Miriam Linsenmeier, Katherine R. Whiteman…·James Shorter

The paper identifies chaperones in the human Hsp70 network that buffer TDP-43 toxicity by reducing aggregates and enhancing solubility.

1 citation

humanproteomics

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BiochemistrybioRxivSep 4, 2023

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

Lin Guo, Jacob R. Mann, Jocelyn C. Mauna…·James Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

DOI 10.1016/j.molcel.2025.12.009

humanbulk RNA-seq

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