Jack D. Rubien

This study uses AI to design protein fragments that regulate biomolecular condensates, showing success in multiple targets and revealing new interaction mechanisms.

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

This paper introduces molecular time capsules to capture and preserve transcriptomic data from living cells, enabling retrospective analysis of gene expression during cellular transitions.

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.