Author

Yan Zeng

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 3 Genomics· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Arun P. WiitaiD· 3 shared Paul J. Phojanakong· 3 shared Veronica SteriiD· 3 shared Amrik S. KangiD· 2 shared Bonell Patiño-EscobariD· 2 shared Fernando Salangsang· 2 shared Juan Antonio Camara Serrano· 2 shared Radhika DalaliD· 2 shared

Activity by Year

2016-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

Arun P. WiitaORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Brain state shapes the polarity of pulsed infrared neural stimulation responses in individual cortical neurons

Peng Fu, Yin Liu, Liang Zhu, Mengqi Wang, Yuan Yu, Hequn Zhang, Yuchen Pei, Shy Shoham, Yan Zeng, Anna Wang Roe, Xi Wang

The paper investigates how brain state affects the polarity of pulsed infrared neural stimulation responses in cortical neurons and develops a method to account for temperature-related fluorescence effects.

bioRxiv · Sep 25, 2026 · PreprintNeuroscience

Deep Learning-based Modeling Enhances Efficacy of Natural Ligand CAR Binders Targeting CD70

Amrik S. Kang, Radhika Dalal, Mingcheng Li, Anupam Anand Ojha, Sujata B. Walunj, Caitlin E. Cornell, Ruyan Rahnama, Abhilash Barpanda, Sanjana Prudhvi, Trishna S. Patel, Mark Aspinall-O’Dea, Beth Walker, Clare Adams, Veronica Steri, Paul J. Phojanakong, , Arun P. Wiita

This study uses deep learning and physics-based modeling to engineer a CD27 variant that improves the efficacy of CD70-targeting CAR T-cells across multiple cancer models.

bioRxiv · Sep 10, 2026 · PreprintCancer Biology

Integrative Genomic, Single-Cell, and Functional Profiling of the CD48-CD244 Axis and NK-Cell Dysfunction in Multiple Myeloma

Bonell Patiño-Escobar, Torsten Steinbrunn, Lucy Maritza Pérez Lugo, Sham Rampersaud, Daniel Dirck Waller, Huimin Geng, Fernando Salangsang, Paul J. Phojanakong, Juan Antonio Camara Serrano, Yan Zeng, Veronica Steri, Oscar A. Aguilar, Constantine S. Mitsiades, Arun P. Wiita

The paper investigates the CD48-CD244 axis in multiple myeloma, showing CD48 enhances NK-cell activation but contributes to NK exhaustion and poor prognosis.

bioRxiv · May 12, 2026 · PreprintCancer Biology

Structure-guided engineering of CCL27 enhances natural ligand CAR T-cells against CCR10 for multiple myeloma

Nikhil Chilakapati, Bonell Patiño-Escobar, Emily Y. Chen, Radhika Dalal, Jonathan de Montagnac, Haley Johnson, Amrik S. Kang, Naomi Akagi, Emilio Ramos, Paul J. Phojanakong, Fernando Salangsang, Yan Zeng, Ajai Chari, Alfred Chung, Anupama Deepa Kumar, , Arun P. Wiita

This paper engineers CCL27 mutants to enhance CAR T-cell efficacy against multiple myeloma by targeting CCR10, achieving results comparable to BCMA CAR-Ts.

bioRxiv · Aug 19, 2025 · PreprintCancer Biology

Phages-bacteria interactions underlying the dynamics of polyhydroxyalkanoates-producing mixed microbial cultures via meta-omics study

Jian Yao, Yan Zeng, Xia Hong, Meng Wang, Quan Zhang, Yating Chen, Min Gou, Ziyuan Xia, Yue‐Qin Tang

This study investigates phage-bacteria interactions in PHA-MMCs using meta-omics, revealing phage influence on community structure and PHA synthesis pathways.

mSystems · Mar 28, 2025Peer-reviewedMicrobiology

Genome of octoploid plant maca (Lepidium meyenii) illuminates genomic basis for high altitude adaptation in the central Andes

Jun Sheng, Wei Chen, Yang Dong, Liangsheng Zhang, Jing Zhang, Yang Tian, Liang Yan, Guanghui Zhang, Xiao Wang, Yan Zeng, Jiajin Zhang, Xiao Ma, Yuntao Tan, Ni Long, Yangzi Wang, , Wen Wang

This study reports the genome of octoploid maca, revealing how whole genome duplications contribute to high altitude adaptation in the Andes.

Molecular Plant · Jul 1, 2016Peer-reviewedGenomics