Arun P. Wiita

This study identifies TM4SF1 as a tumor-associated antigen in biliary tract cancers and shows anti-TM4SF1 CAR-T cells inhibit tumor growth in vitro and in vivo.

This study uses deep learning and physics-based modeling to engineer a CD27 variant that improves the efficacy of CD70-targeting CAR T-cells across multiple cancer models.

This study identifies a multi-subunit autophagic capture complex that degrades ER-stalled MHC-I in pancreatic cancer, reducing immunogenicity.

This paper expands structural surfaceomics to identify cancer-specific protein conformations across multiple tumor models, revealing potential immunotherapy targets through crosslinking mass spectrometry and structural modeling.

The paper investigates the CD48-CD244 axis in multiple myeloma, showing CD48 enhances NK-cell activation but contributes to NK exhaustion and poor prognosis.

This study shows that affinity-matured CD72-targeting nanobody CAR T-cells improve in vitro efficacy against CD72-low tumors but show limited in vivo benefit, while CD72 expression remains stable after CD19 resistance in B-cell malignancies.

This study uses CRISPR screens to identify PTGES3 as a novel modulator of AR protein levels and function in prostate cancer, showing its role in therapy resistance.

This paper develops dual-antigen targeting CAR-T cells against CD70 and active integrin β2 to overcome AML antigen heterogeneity and reduce off-tumor toxicity.

This study shows that PKR-mediated integrated stress response drives PVOD pathogenesis in mice, with PKR knockout preventing vascular remodeling and pulmonary hypertension.

This study demonstrates promising preclinical efficacy of aITGB2-targeted radiotheranostics for selective imaging and therapy in AML.

This paper engineers CCL27 mutants to enhance CAR T-cell efficacy against multiple myeloma by targeting CCR10, achieving results comparable to BCMA CAR-Ts.

AlphaCross-XL automates mapping of crosslinked peptides to protein structures at proteome scale, enabling analysis of thousands of proteins.

Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.

Structure-optimized CD27-based CAR-T cells targeting CD70 show >80-fold improved expansion in vivo and offer a potential therapy for high-risk multiple myeloma patients.

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

This study creates isogenic models of the 22q11.2 'A-B' deletion using CRISPR in iPS cells, revealing altered neuronal phenotypes through transcriptomic and proteomic analysis.