Xiao Wang

Chimeric archaeal BHB-human pre-tRNA scaffold HARBOR system enables versatile production of functional circular RNA modalities

The paper introduces the HARBOR system for producing functional circular RNAs with high efficiency and versatility in both cells and vivo.

Torsins Organize CLCC1 Assembly to Safeguard ER Bilayer and Lipid Homeostasis

The paper identifies CLCC1 as a client of Torsin ATPases, showing they organize CLCC1 to maintain ER bilayer and lipid homeostasis, with implications for MASH development.

Circular RNA aptamers as superb sub-stoichiometric chaperones of TDP-43 condensation

This paper identifies two circular RNA aptamers that act as sub-stoichiometric chaperones to suppress pathological TDP-43 condensation and rescue splicing and motor dysfunction in vivo.

scTrends: automated classification and strength quantification of gene expression trends along pseudotime in single-cell RNA-seq

scTrends classifies and quantifies gene expression trends along pseudotime in single-cell RNA-seq datasets, revealing diverse expression patterns across biological processes.

Betrixaban Activates cGAS and ERVs to Promote Dual Nucleic-Sensing Antiviral Immunity

This paper shows Betrixaban activates cGAS and ERVs to trigger antiviral immunity through dual pathways, suggesting its repurposing as a broad-spectrum antiviral.

The enhanced multi-tissue atlas of regulatory effects in cattle

The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.

Transcriptomics-based modeling of methionine metabolism effectively estimates sample-wise DNA methylation activity and epigenetic aging

This paper develops TDMA, a transcriptomics-based model to estimate DNA methylation activity and epigenetic aging from bulk, single-cell, and spatial transcriptomics data.

S3R: Modeling spatially varying associations with Spatially Smooth Sparse Regression

S3R models spatially varying associations in spatial transcriptomics data by estimating location-specific coefficients with structured sparsity and smoothness penalties, showing effectiveness in synthetic and real datasets.

RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion

This study identifies A1CF as a regulator of plasma triglycerides through posttranscriptional control of VLDL secretion and intracellular stress pathways.

Genome of octoploid plant maca (Lepidium meyenii) illuminates genomic basis for high altitude adaptation in the central Andes

This study reports the genome of octoploid maca, revealing how whole genome duplications contribute to high altitude adaptation in the Andes.

High-throughput Screening and CRISPR-Cas9 Modeling of Causal Lipid-associated Expression Quantitative Trait Locus Variants

The paper validates two lipid-associated expression quantitative trait loci variants using CRISPR-Cas9 and functional assays.

A population density and moment-based approach to modeling domain Ca-mediated inactivation of L-type Ca channels

The paper develops a population density and moment-based model to study Ca2+-mediated inactivation of L-type Ca channels, showing how domain dynamics affect whole-cell currents.

Ca-activation kinetics modulate successive puff/spark amplitude, duration and inter-event-interval correlations in a Langevin model of stochastic Ca release

The paper uses a Langevin model to show how Ca2+ channel kinetics affect correlations in puff/spark amplitude, duration, and inter-event intervals in stochastic Ca release.