Huanghe Yang

The paper identifies Gardos as an amplifier of PIEZO1-TMEM16F signaling in red blood cells, enhancing Ca2+ entry and PS externalization, and suggests it as a therapeutic target for diseases like sickle cell disease.

This paper shows that cannabidiol inhibits PIEZO channels in red blood cells, reducing calcium overload and related pathologies in hereditary xerocytosis and sickle cell disease.

This paper identifies PIEZO1-TMEM16F coupling as a mechanism driving phosphatidylserine exposure in sickle red blood cells and proposes targeting this pathway to reduce disease complications.

This study shows PIEZO1 is essential for trophoblast fusion and placental development in mice by activating TMEM16F and phosphatidylserine externalization.

This study shows that OSCA/TMEM63 proteins, like TMEM16s, can permeate ions and phospholipids, highlighting conserved functional potential across the TCS superfamily.

This study shows that reducing midline thalamus neuron bursting prevents absence seizures in a mouse model by enhancing vigilance and suppressing seizure activity.

This study identifies TMEM16F as a regulator of angiogenesis through intracellular signaling, showing impaired retinal angiogenesis in TMEM16F-deficient mice and altered VE-cadherin and Src kinase activity in human endothelial cells.

This study investigates the neuronal mechanism of a BK channelopathy in absence epilepsy and movement disorders using a knock-in mouse model and finds that BK channel inhibition can mitigate seizures and motor deficits.