Author

Yaohui He

University of South ChinaPrimary ORCID profile (0000-0002-8235-8924 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Yaohui HeiD2 papers · Xiamen University

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ailing Zou· 1 shared Caiming WuiD· 1 shared Dong Tan· 1 shared Gang FaniD· 1 shared Hanqi LiuiD· 1 shared Hui CaoiD· 1 shared Ji Li· 1 shared Jie Ouyang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Ailing Zou

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2 papers

Recent·Most cited

FASN Inactivation-induced Progranulin (GRN) Expression Promotes Lysosome-dependent Cell Death to Suppress Leukemogenesis

Meng Su, Qinglin Li, Zhiyi Lv, Xinshu Xie, Yating Lu, Yaohui He, Hanqi Liu, Hui Cao, Jie Ouyang, Qiao Zhang, Xuezhen Ma, Yexin Yang, Ailing Zou, Kang Liu (423471), Shuqian Xu, , Yang Mei

This study shows that inhibiting FASN leads to lysosome-dependent cell death via GRN expression, suppressing leukemogenesis in myeloid leukemia.

Cell Reports · Mar 1, 2026Peer-reviewedCancer Biology

Potent Efficacy of Computer-Aided Designed Peptide Degrader Drug on PCSK9-Mediated Hypercholesterolemia

Gang Fan, W P Guo, Jingfen Lu, Yaohui He, Jinhui Zha, Qingping Zhang, Yijia Chen, Dong Tan, 唐志晗, Jing Yang, Zhijian Yu, Miao Liu

This study develops a computer-aided designed peptide degrader, Cadd4, which reduces PCSK9 levels and lowers LDL-C in mice and human liver tissue without toxicity.

Metabolism · Dec 24, 2025Peer-reviewedPharmacology & Toxicology