Pharmacology & ToxicologyMetabolismPeer-reviewed
Potent Efficacy of Computer-Aided Designed Peptide Degrader Drug on PCSK9-Mediated Hypercholesterolemia
Gang Fan, W P Guo, Jingfen Lu…·Miao Liu
This study develops a computer-aided designed peptide degrader, Cadd4, which reduces PCSK9 levels and lowers LDL-C in mice and human liver tissue without toxicity.