Jing Yang

SMAD3-driven cell state transitions underpin immunoresistance in bladder cancer

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

Low-Density Lipoprotein Cholesterol and Cerebral Pericyte Dysfunction in Acute Ischemic Stroke: Clinical and Experimental Evidence

This study links LDL-C to cerebral pericyte dysfunction in acute ischemic stroke through clinical and experimental evidence, showing oxidative stress and type-I interferon signaling changes.

Metabolic Targeting of SREBP1 Reprograms the Obesity-Driven Ascites Immune Microenvironment and Enhances Chemotherapy Response in Obesity-Associated Ovarian Cancer

This study shows that inhibiting SREBP1 with Nelfinavir improves chemotherapy response in obesity-associated ovarian cancer by reprogramming the immune microenvironment.

A virus co-opts vector's m⁶A machinery for adaptive compensation

The paper shows TYLCV co-opts its vector's m6A machinery to enhance reproductive fitness in resistant whiteflies, revealing a mechanism for adaptive virus-vector interactions.

RNA m6A demethylase ALKBH4 governs whitefly development

This study identifies ALKBH4 as an m6A demethylase in whiteflies, showing its role in reversing mRNA methylation and regulating development.

Research Process Graph: LLM-Driven Extraction and Hierarchical Organization of Research Logic

This paper creates a structured atlas of research logic in Plant Cell by converting articles into Research Process Graphs using LLMs, revealing patterns in research methods and findings.

Loss of Arginase 2 Promotes Lung Metastasis in immune-competent hosts via Nitric Oxide Synthase 2-Dependent Th17 Response

This study identifies ARG2 deficiency in tumor cells as a driver of lung metastasis via NOS2-dependent Th17 responses in immune-competent hosts.

Genome assembly of Firmina major, an endangered savanna tree species endemic to China

The paper presents the first high-quality genome assembly of Firmina major, an endangered tree species, providing insights for conservation efforts.

DNA Data Storage Architecture via Ligation of Dynamic DNA Bytes

This paper introduces a modular DNA storage system using dynamic DNA bytes that enables reconfigurable, rewritable data storage with CRUD operations and error correction.

Potent Efficacy of Computer-Aided Designed Peptide Degrader Drug on PCSK9-Mediated Hypercholesterolemia

This study develops a computer-aided designed peptide degrader, Cadd4, which reduces PCSK9 levels and lowers LDL-C in mice and human liver tissue without toxicity.

Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain

This study shows BDNF supports pericyte and vascular health in aging brains by activating Akt signaling to increase PDGFRβ and CD13 expression.

Calpain cleaves the carboxyl terminus of TRPV1 and modulates receptor tachyphylaxis

This study shows that calpain cleaves TRPV1's carboxyl terminus, reducing its membrane localization and increasing resistance to tachyphylaxis during repeated capsaicin exposure.

Genetic structure analysis on leopard cat reveals the effects of habitat fragmentation on subpopulation differentiation in Beijing

The paper analyzes genetic structure in leopard cats to assess habitat fragmentation effects, finding differentiation in the Songshan subpopulation.

Landscape of Dysregulated Placental RNA Editing Associated with Preeclampsia

The paper identifies widespread RNA editing dysregulation in placental tissue from preeclampsia patients and links it to altered LEP expression and disease pathogenesis.