Cancer BiologybioRxivPreprint
Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy in EGFR-mutated non-small cell lung cancer
Satoshi Nakamura, Daisuke Shibahara, Kentaro Tanaka…·Isamu Okamoto
The paper uses spatial transcriptomics to analyze pre- and post-treatment tumor samples, identifying fibroblast activation and tumor heterogeneity as factors in early EGFR-TKI resistance.