Ying Chen

In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling

This paper introduces Hi-APEX, a H2O2-independent APEX2 variant for in vivo spatial multi-omics, showing improved performance in capturing redox-sensitive processes and enabling in vivo applications.

Multidimensional atlas of RNA-regulated proteins revealed by RNA-dependent thermal proteome profiling

This paper introduces RTPP to identify RNA-regulated proteins and generates a tissue-specific atlas of RNA-protein interactions, revealing novel orphan proteins and organ-specific dysregulation in Alzheimer's disease.

Chromosome-level genome assembly of Calotes wangi with dynamic colour variation

This paper presents a chromosome-level genome assembly of Calotes wangi, identifying expanded gene families related to steroid metabolism and epigenetic processes.

Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2

The paper identifies a novel small RNA, ASpks2, in Mycobacterium tuberculosis that promotes bacterial survival in macrophages by targeting polyketide synthase 2.

Catabolism of extracellular glutathione supplies amino acids to support tumor growth

This study shows that extracellular glutathione supports tumor growth by providing amino acids through catabolism, and inhibiting this process slows tumor growth.

Neutrophils are critical for placental and fetal infection with the human pathogen Listeria monocytogenes

The paper identifies maternal neutrophils as a survival niche for Listeria monocytogenes, facilitating placental and fetal infection during pregnancy.

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors

This paper introduces OncoSCOUT, a method using engineered T cells with protease-activatable receptors to detect early-stage cancer with improved sensitivity compared to existing biomarkers.

A Complete Telomere-to-Telomere Diploid Reference Genome for Indian Population

The paper presents a high-quality, gapless diploid reference genome for an Indian population, revealing extensive structural variation and improved performance for genomic analysis in South Asian samples.

A novel immunogene therapy to cancer with high tumor selectivity and safety

This paper develops a novel immunogene therapy that selectively targets cancer cells to enhance immune responses while minimizing toxicity to healthy tissues.

Action-specific feature processing in the human visual cortex

This study shows that action-specific intentions influence visual cortex processing of object orientation several seconds after viewing, with effects starting in primary visual cortex and extending to other visual areas.

TSLP-mediated inflammatory factors production contributes to metastatic breast cancer-induced bone cancer pain in mice

This study shows that TSLP from breast cancer cells increases inflammatory factors, leading to bone cancer pain in mice, and inhibiting TSLP reduces pain.

Anxiety-like but not despair-like behaviors are further aggravated by chronic mild stress in the early stages of APPswe/PS1dE9 transgenic mice

This study shows chronic mild stress worsens anxiety-like behaviors but not despair-like behaviors in early AD mouse models, along with increased neuroinflammation and corticosterone normalization.