Cancer BiologybioRxivPreprint
EZH1-dependent H3K27me1 is an adaptive chromatin barrier that limits DNMT inhibitor response in colorectal cancer
Alison A. Chomiak, Ashley K. Wiseman, Joel A. Hrit…·Scott B. Rothbart
This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.
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