Extracellular vesicle cross-linking coupled with solid-phase purification facilitates discovery of ribonucleoprotein complexes assembled on EV RNAs.
Rajat Dhyani, Stephen Clarke, Masashi Kuroda, Yohei Sanada, Marc Gorum, Bahnisikha Barman, Alissa M. Weaver, Takahisa Nakamura, Manuel Ascano
This paper introduces two methods, EV-CLASP and EV(r)-CLASP, to study RNP complexes on EV RNAs, revealing post-transfer interactions and intra-vesicular compositions.
bioRxiv · Oct 6, 2026 · PreprintCancer Biology