Manuel Ascano

Fatty Acid Synthase Binds Cellular mRNAs and its Depletion Reduces Translational Efficiency

This study identifies FASN's RNA binding sites and shows its depletion reduces translational efficiency of associated mRNAs.

Extracellular vesicle cross-linking coupled with solid-phase purification facilitates discovery of ribonucleoprotein complexes assembled on EV RNAs.

This paper introduces two methods, EV-CLASP and EV(r)-CLASP, to study RNP complexes on EV RNAs, revealing post-transfer interactions and intra-vesicular compositions.

The Incoming Influenza Genome Assembles a Host RBP Network that Orchestrates Viral RNA Synthesis

The paper identifies host RNA binding proteins interacting with incoming influenza virus RNA and shows their roles in viral replication.

Early Host-Virus RNA Interactions Reveal SPEN-Driven m6A Regulation as a Major Determinant of Henipavirus Infection

The paper identifies SPEN-driven m6A regulation as a key factor in henipavirus infection by analyzing host-virus RNA interactions using VIR-CLASP.

ELAVL1 Primarily Couples mRNA Stability with the 3'UTRs of Interferon Stimulated Genes

This study identifies ELAVL1's context-dependent binding sites and regulatory role in immune activation by integrating multiple high-throughput approaches.