Cancer BiologybioRxivPreprint
Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain development
Charles P. Couturier, Shamini Ayyadhury, Phuong U. Le…·Kevin Petrecca
The paper uses single-cell RNA-seq to show glioblastoma recapitulates normal brain development, identifying a conserved trilineage hierarchy with glial progenitor-like cells as the origin of cancer heterogeneity and therapeutic targets.