Yu Zhou

The paper investigates whether β2 and β3a BK channel regulatory subunits can coassemble in the same channel complex and finds they do so randomly.

The paper investigates how mutations in BK channel β subunit residues affect inactivation by altering access to the central cavity through the side portal pathway.

The paper determines high-resolution structures of Slo1 channels with mutations and LRRC26 subunits to elucidate voltage and auxiliary subunit regulation mechanisms.