Genomic splice-donor disruption rescues systemic disease in progeria
Wei Zhu Jin, Jingchun Ma, Hao Yuan, Yu Zou, Zixuan Zhang, Jinhang Zuo, Sheung Kin Ken Wong, Tuo Li, Xiaomei Lu, Zhongjun Zhou
This paper shows that disrupting a faulty splice donor site in progeria reduces toxic protein levels and extends lifespan in mice.
bioRxiv · Sep 18, 2026 · PreprintCell Biology