Genomic splice-donor disruption rescues systemic disease in progeria
Wei Zhu Jin, Jingchun Ma, Hao Yuan…·Zhongjun Zhou
This paper shows that disrupting a faulty splice donor site in progeria reduces toxic protein levels and extends lifespan in mice.
Author
Chinese Academy of Sciences
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
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Wei Zhu Jin, Jingchun Ma, Hao Yuan…·Zhongjun Zhou
This paper shows that disrupting a faulty splice donor site in progeria reduces toxic protein levels and extends lifespan in mice.
Jianzhen Lin, Zhenzhen Xun, Fangze Qian…·Han Liang
This study identifies a co-evolved tumor-immune interaction involving KRAS signaling and LILRBhigh macrophages that drives PDAC recurrence and presents a therapeutic strategy targeting this axis.
Yanmei Zhang, Gongchao Jing, Rongze Chen…·Luyang Sun
RamEx is an R package for high-throughput microbial ramanome analysis with quality assessment and classification, achieving high accuracy in anomaly detection and phenotyping.
Wei Lv, Xiaoguang Pan, Peng Han…·Yonglun Luo
This study identifies and characterizes over one million urinary cell free eccDNAs in healthy adults, revealing their genomic distribution, sequence features, and potential role of direct repeats in their biogenesis.