Yuqi Yan

A general method to develop excitation ratiometric neuropeptide sensors with enhanced sensitivity for in vivo applications

The paper introduces a method to create excitation ratiometric neuropeptide sensors with improved sensitivity for in vivo use by using dual excitation and fluorescence correction.

A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo

This paper develops a genetically encoded fluorescent sensor, GRABPGE2-1.0, to monitor spatiotemporal PGE2 dynamics in vivo with high resolution.

Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior

The paper introduces synthetic GPCRs that can be programmed to control cell behavior in response to specific antigens, using modular design for versatile applications.

A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.

Dual-color GRAB sensors for monitoring spatiotemporal serotonin release in vivo

This paper develops dual-color GRAB sensors to monitor spatiotemporal serotonin release in vivo, revealing uniform and gradient release patterns and seizure-induced waves.

Genetically encoded sensors for measuring histamine release both in vitro and in vivo

This paper develops genetically encoded sensors to measure histamine release in vitro and in vivo, showing high sensitivity and specificity for extracellular histamine detection.