BiophysicsbioRxivPreprint
Not All Charges Are Equal: Side-Chain Chemistry Reshapes the Disordered Ensemble of α-synuclein
Gil Koren, Nuno Fernandes, Asaf Sivan…·Roy Beck
This paper shows that arginine substitutions, despite similar charge, compact α-synuclein more than lysine, accelerating amyloid formation and reshaping its disordered ensemble.
DOI 10.64898/2026.06.07.730657