Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance
G. Therizols, Z. Bash-Imam, B. Panthu, C. Machon, A. Vincent, S. Nait Slimane, M. Garcia, F. Laforets, V. Marcel, J. Boubaker-Vitre, G. Souahlia, M.-A. Albaret, H. C. Mertani, M. Prudhomme, M. Bertrand, , J.-J. Diaz
This study shows that 5-FU treatment creates fluorinated ribosomes that selectively translate survival genes, promoting drug tolerance in cancer cells.
bioRxiv · Jun 4, 2020 · PreprintCancer Biology