Author

C. Machon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Guitton· 3 shared F. Catez· 2 shared J.-J. Diaz· 2 shared A. Nicolas· 1 shared A. Vincent· 1 shared B. Gibert· 1 shared B. Panthu· 1 shared C. Chaveroux· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

J. Guitton

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Author profile →

3 papers

Recent·Most cited

Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer.

M. Piecyk, M. Triki, P.-A. Laval, C. Duret, J. Fauvre, L. Cussonneau, C. Machon, J. Guitton, N. Rama, B. Gibert, G. Ichim, F. Catez, F. Bourdelais, S. Durand, J.-J. Diaz, , C. Chaveroux

This study shows GCN2 regulates 47S rRNA synthesis in colon cancer cells under different nutrient conditions, affecting cell survival and response to chemotherapy.

bioRxiv · Feb 8, 2023Cancer Biology

Cholesterol biosynthetic pathway induces cellular senescence through ERRa

D. V. Ziegler, M. Vernier, J. Czarnecka-Herok, C. Scholtes, C. Machon, J. Guitton, J. Rieusset, V. Giguere, N. Martin, D. Bernard

This study shows the mevalonate pathway promotes cellular senescence via ERRα, causing mitochondrial dysfunction, ROS, DNA damage, and p53-dependent senescence.

bioRxiv · Oct 20, 2021Cell Biology

Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance

G. Therizols, Z. Bash-Imam, B. Panthu, C. Machon, A. Vincent, S. Nait Slimane, M. Garcia, F. Laforets, V. Marcel, J. Boubaker-Vitre, G. Souahlia, M.-A. Albaret, H. C. Mertani, M. Prudhomme, M. Bertrand, , J.-J. Diaz

This study shows that 5-FU treatment creates fluorinated ribosomes that selectively translate survival genes, promoting drug tolerance in cancer cells.

bioRxiv · Jun 4, 2020 · PreprintCancer Biology